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ROS level regulation and cell metabolism both affect ferroptosis, and both processes are influenced by heat stress: when increased iron uptake or decreased storage causes iron overload, free iron generates ROS via the Fenton reaction, directly triggering ferroptosis-related damage

No, they can also result from physical overexertion, poor sleep, stress, or nutritional deficiencies

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The Mn-SOD and Fe-SOD groups are closely linked to one another, according to sequence and structural comparisons

Studies have shown that it exerts powerful anti-ferroptotic effects through two mechanisms: Protecting CoQ10 from depletion and directly inhibiting lipid peroxidation (34,35)